Entirely, our details offer evidence to the opportunity of mixing CX-5461 and PARPi for enhancing the treatment method of HR-deficient HGSOC. We reveal that CX-5461 boosts the artificial lethal conversation of PARPi with HRD and clearly present that CX-5461 has a distinct system of action to PARPi. Importantly, we characterized BRCA-mutated and MYC